Status of candidate vaccine virus development for the current Influenza A(H1N1) virus
Publication date: 8 May 2009
For the current influenza A(H1N1) virus, WHO Collaborating Centres for influenza (WHO CCs), Essential Regulatory Laboratories (ERLs) and other institutions are developing candidate vaccine viruses under the coordination of WHO1. Once a vaccine virus is available, WHO will announce the availability on its public website2. For general queries, please email to [email protected]
Candidate vaccine viruses using reverse genetics technology are being developed by:
* WHO CC in the Centers for Disease Control and Prevention (CDC), Atlanta USA, from A/California/4/2009(H1N1)swl. Expected availability end of May. Email queries to: [email protected]
* ERL in the National Institute for Biological Standards and Control (NIBSC), UK, from A/California/7/2009(H1N1)swl and A/England/195/2009 (H1N1)swl. Expected availability end of May. Email queries to: [email protected]
* ERL in the Centre for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) USA, from A/California/4/2009(H1N1)swl and A/Texas/5/2009(H1N1)swl. Expected availability not yet known. Email queries to: [email protected]
* WHO CC at the St. Jude Children's Research Hospital, Memphis USA, from A/California/4/2009(H1N1)swl, A/New York/20/2009(H1N1)swl and A/Ohio/7/2009 (H1N1)swl. Expected availability not yet known. Email queries to: [email protected]
* WHO CC at National Institute of Infectious Diseases (NIID), Japan, from A/California/4/2009(H1N1)swl and A/California/7/2009(H1N1)swl. Expected availability not yet known. Email queries: [email protected]
* CSL Limited, Australia, from A/California/4/2009(H1N1)swl and A/California/7/2009(H1N1)swl. Expected availability not yet known. Email queries: [email protected]
Candidate vaccine viruses using classical reassortment technology are being developed by:
* ERL NIBSC, UK, from A/California/7/2009(H1N1)swl, an egg virus isolate. Expected availability not yet known. Email queries: [email protected]
* New York Medical College, USA, from A/California/7/2009(H1N1)swl. Expected availability not yet known. Email queries: [email protected]
* CSL Limited, Australia, from A/California/7/2009(H1N1)swl. Expected availability not yet known. Email queries: [email protected]
Development of vaccine potency reagents for inactivated vaccines against Influenza A(H1N1) is planned in:
1 WHO coordinates WHO CCs, National Influenza Centers and ERLs. This Network is monitoring the evolution of influenza viruses, both seasonal and those with potential to cause a pandemic, including the current influenza A(H1N1). The Network also provides recommendations and updates on diagnostics, monitors the susceptibility of emerging influenza viruses to antiviral drugs, and selects, develops and distributes vaccine viruses.
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